Urol. praxi. 2024;25(4):185-193 | DOI: 10.36290/uro.2024.069

Diabetes mellitus from the point of view of a urologist

doc. MUDr. Jozef Marenčák, PhD.
Bratislava

Diabetes mellitus (DM) is a global epidemic characterized by elevated blood glucose levels with significant morbidity and mortality. DM can lead to acute and chronic complications in virtually all body organs, including the urogenital system. The issue of diagnosis and treatment of diabetic patients with urological and andrological problems is complex, extremly serious and constantly evolving. The article deals with the most common urological conditions that are specific to DM. Urological complications can last an unrecognizably long time, often oligosymptomatically, but they are often life-threatening for patients. The proper tretment of these diseases does not consist only in the stabilization of the urological problem, but also in the setting and adjustment of DM therapy. It can be said that diabetes increases the risk and severity of urological problems, and on the contrary, urological problems (especially inflammation) can lead to DM decompensation. Cooperation between a urologist and a diabetologist appears to be a necessity.

Keywords: diabetes mellitus, urological complications, diagnosis, treatment.

Accepted: November 11, 2024; Published: November 25, 2024  Show citation

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Marenčák J. Diabetes mellitus from the point of view of a urologist. Urol. praxi. 2024;25(4):185-193. doi: 10.36290/uro.2024.069.
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References

  1. Lotti F, Maggi M. Effects of diabetes mellitus on sperm quality and fertility outcomes: clinical evidence. Andrology, 2023; 11:399-416. https://doi.org/10.1111/andr.13342. Go to original source... Go to PubMed...
  2. Dillon B, Ang L, Pop-Busui R. Spectrum of diabetic neuropathy: new insights in diagnosis and treatment. Annu Rev Med. 2024;75:293-306. Go to original source... Go to PubMed...
  3. Bonkat G, Bartoletti R, Bruyere F, et al. EAU guidelines on urological infections. https://uroweb.org/guidelines, prístup od 10. 4. 2024.
  4. Ryšánková M. Urologické komplikace diabetu. Vnitř Lék, 2023;69(2):E26-E30. Go to original source... Go to PubMed...
  5. Ryšánková M, Hurtová M. Urologické nemoci u diabetického pacienta. Urol Praxi. 2022;23(2):58-65. Go to original source...
  6. Cooper K, Badalato G, Rutman M. Infections of the urinary tract. In: Partin A, Dmochowski R, Kavoussi L, et al. Campbell - Walsh Urology, 12th edition, Saunders Elsevier 2021; ISBN 978-0-323-54642-3: 1129-1201.
  7. Marenčák J. Pacient s diabetes mellitus v urologickej ambulancii. Via pract, 2023;20(3):104-111.
  8. Papp S, Zimmern P. Recurrent urinary tract infections and type 2 diabetes mellitus: a systematic review predominantly in women. Fron Urol, 2023;3:1275334. doi: 10.3389/fruro.2023.1275334. Go to original source... Go to PubMed...
  9. Karslioglu M, Yilmaz M. Exploring the nexus: prevalence, risk factors, and clinical correlations of urinary tract infections in diabetes mellitus patients - a comprehensive retrospective analysis. Annatolian Curr Med J. 2024;6(1):93-96. Go to original source...
  10. Bishoff J, Rastinehad A. Urinary tract imaging - basic principles of CT, MRI, and plain film imaging. In: Partin A, Dmochowski R, Kavoussi L, et al. Campbell - Walsh Urology, 12th edition, Saunders Elsevier 2021; ISBN 978-0-323-54642-3: 28-67.
  11. Marenčák J. Emfyzematózna pyelonefritída. Lek listy. 2020;25(6):5-7.
  12. Kawaguchi Y, Mori, Izumi Y, et al. Renal papillary necrosis with diabetes and urinary tract infection. Intern Med, 2018; 57(22):3343 doi: 10.2169/internalmedicine. Go to original source...
  13. Marenčák J. Fournierova gangréna. Medical practice. 2021;26(4):16-19.
  14. Bhatia S. Multidrug resistant urinary tract infection. In: Khera R. Update on urinary tract infection. Jaypee Brothers Medical Publishers Ltd. 2018; ISBN 978-93-5270-172-8: 111-123. Go to original source...
  15. Marenčák J. Uroinfekcia z hľadiska bakteriálnej rezistencie. Via Practica. 2021;18(1):27-32. Go to original source...
  16. Naber K, Tirán-Sacedo J, Wagenlehner F. Psychosocial burden of recurrent uncomplicated urinary tract infections. GMS Inf Dis. 2022;10(1):1-9.
  17. Marenčák J. Súčasný manažment recidivujúcich, nekomplikovaných zápalov dolných močových ciest u žien. Klin Urol. 2023;19(3):116-124.
  18. Mulawkar P. Emphysematous pyelonephritis. In: Khera R. Update on urinary tract infection. Jaypee Brothers Medical Publishers Ltd. 2018; ISBN 978-93-5270-172-8: 32-49. Go to original source...
  19. Marenčák J. Bakteriálna prostatitída. Lek listy. 2021;26(6): 12-15.
  20. Tallai B, Gulistan T, Alrayashi M, et al. A rare presentation of renal papillary necrosis in a COVID-19-positive patients. Case Rep Urol, 2021; 6611861. doi: 10.1155/2021/6611861. Go to original source... Go to PubMed...
  21. Radcliffe R, Khan M. Mortality associated with Fournier´s gangrene remains unchanged over 25 years. BJU Int, 2020;125(4):610-616. Go to original source... Go to PubMed...
  22. Insua-Pereira I, Ferreira P, Teixeira E, et al. Fournier´s gangrene: a review of reconstructive options. Cent Eur J Urol. 2020;73(1):74-79.
  23. Huang C, Lien C, Lee S, et al. Adult balanoposthitis patients have a higher risk of type 2 diabetes mellitus: a nationwide population based cohort study. Urol Sci. 2018;29(1):55-60. Go to original source...
  24. Agró E, Rosato E, Wagg A, et al. How to make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using markers and microbiome data, in order to personalize therapy? ICI-RS 2023: Part 1. Neurol Urodyn. 2024;1-11. doi: 10.1002/nau.25377. Go to original source... Go to PubMed...
  25. Khan J, Shaw S. Risk of multiple lower and upper urinary tract problems among male older adults with type-2 diabetes: a population based study. The Aging Male. 2023;26:1, 2208658, DOI: 10.1080/13685538.2023.2208658. Go to original source... Go to PubMed...
  26. Xin C, Fan H, Xie J, et al. Impact of diabetes mellitus on lower urinary tract symptoms in benign prostatic hyperplasia patients: a meta - analysis. Front Endocrinol (Lausanne), 2022; 12:741748.doi: 10.3389/fendo.2021.741748. eCollection 2021. Go to original source...
  27. Jo J, Kim H, Bang W, et al. Effect of diabetes mellitus on symptomatic improvement after surgery for benign prostatic hyperplasia in patients with lower urinary tract symptoms and its relations with prostatic urethral angulation. Int Neurourol J. 2023;27(2):116-123. Go to original source... Go to PubMed...
  28. Eskidemir U, Simsir A, Simsir I, et al. Evaluation of lower urinary tract functions in diabetic patients. J Urol Surg. 2019;6(1):46-53. Go to original source...
  29. Cornu J, Gacci M, Hashim H, et al. EAU guidelines on management of non-neurogenic male lower urinary tract symptoms (LUTS). https://uroweb.org/guidelines, prístup od 10. 4. 2024.
  30. Fwu Ch, Schulman I, Lawrence J, et al. Association of obesity, metabolic syndrome, and diabetes with urinary incontinence and chronic kidney disease: analysis of the national health and nutrition examination survey, 2003-2020. J Urol. 2024; 211: 124-133. https://doi.org/10.1097/JU.0000000000003761. Go to original source... Go to PubMed...
  31. Augustine J, Wee A, Krishnamurthi V, et al. Renal insufficiency and ischemic nephropathy. In: Partin A, Dmochowski R, Kavoussi L, et al. Campbell - Walsh Urology, 12th edition, Saunders Elsevier 2021; ISBN 978-0-323-54642-3: 1921-1935.
  32. DeLay K, Haney N, Hellstrom W. Modifying risk factors in the management of erectile dysfunction: a review. World J Mens Health. 2016;34(2):89-100. Go to original source... Go to PubMed...
  33. Salonia A, Bettocchi C, Capogrosso P, et al. EAU guidelines on sexual and reproductive health.). https://uroweb.org/guidelines, prístup od 10. 4. 2024.
  34. Burnett A, Ramasamy R. Evaluation and management of erectile dysfunction. In: Partin A, Dmochowski R, Kavoussi L. et al. Campbell - Walsh Urology, 12th edition, Saunders Elsevier 2021; ISBN 978-0-323-54642-3: 1513-1538.
  35. Blair Y, Doherty L, Temprosa M, et al. Prevalence and predictors of erectile dysfunction among men in the diabetes prevention program outcome study. J Diabetes Complications. 2024;38(2):108669. Go to original source... Go to PubMed...
  36. Niederberger C, Ohlander S, Pagani R. Male infertility. In: Partin A, Dmochowski R, Kavoussi L. et al. Campbell - Walsh Urology, 12th edition, Saunders Elsevier 2021; ISBN 978-0-323-54642-3: 1428-1452.
  37. Huang R, Chen J, Guo B, et al. Diabetes - induced male infertility: potential mechanisms and treatment options. Mol Med. 2024;30:11, https://doi.org/10.1186/s10020-023-00771-x. Go to original source... Go to PubMed...
  38. Strohmaier W. Infection induced urinary stones. In: Bjerklund-Johannsen T, Wagenlehner F, Matsumoto T. et al. Urogenital infections and inflammations. Duesseldorf: GMS 2017; DOI: 10.5680/lhuii000017-25. Go to original source...
  39. Skolarikos A, Jung H, Neisius A, et al. EAU guidelines on urolithiasis. https://uroweb.org/guidelines, prístup od 10. 4. 2024.
  40. Rašiová M, Kozárová M. Diabetes mellitus a malígne nádory. Int med. 2013;13(1):29-33.
  41. Cornford P, Tilki D, van den Bergh R, et al. EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate cancer. https://uroweb.org/guidelines, prístup od 10. 4. 2024.
  42. Witjes J, Bruins H, Carrión A, et al. EAU guidelines on muscle invasive and metastatic bladder cancer. https://uroweb.org/guidelines, prístup od 10. 4. 2024.
  43. Lee H, Song B, Kwak C, et al. Diabetes mellitus as an independent predictor of survival of patients surgically treated for renal cell carcinoma: a propensity score matching study. Eur Urol Suppl. 2016;15(3):e978. Go to original source...
  44. Akshay J. Top 5 medications that can increase blood glucose levels. Medscape, Jan 30, 2024.
  45. Lin E, Garmo H, Hemelrijck M, et al. Diabetes control in men with type 2 diabetes mellitus and prostate cancer treated with GnRH agonists: a nationwide, population - based cohort study. Eur Urol. 2021;79(S1):S1188. Go to original source...
  46. Merseburger A, Bahl A, Sodatonou H, et al. New or worsening type 2 diabetes mellitus (T2DM) in men treated with enzalutamide (ENZ) or abiraterone acetate (AA) for metastatic castration resistant prostate cancer (mCRPC): EVADE study. EMUC23: Poster session, 15th European Multidisciplinary Congress on Urological Cancers, 04 November 2023; P:111. Go to original source...
  47. Adil M, Khan R, Ghosh P, et al. Pioglitazone and risk of bladder cancer in type 2 diabetes mellitus patients: a systematic literature review and meta-analysis of observational studies using real-world data. Clin Epidem and Glob Health. 2018;6(2):61-68. Go to original source...
  48. Margel D, Urbach D, Lipscombe L, et al. Metformin use in all cause and prostate cancer specific mortality among men with diabetes. J Clin Oncol. 2013;31(25):3069-3075. Go to original source... Go to PubMed...
  49. Chang C, Wang C, Jhan J, et al. The protective effect of metformin in upper tract urothelial carcinoma patients with type 2 diabetes. Eur Urol. 2021;79(S1):S1100. Go to original source...
  50. Paik J, Tesfaye H, Curhan G, et al. Sodium - glukose cotransporter 2 inhibitors and nephrolithiasis risk in patients with type 2 diabetes. Jama Intern Med. 2024;184(3):265-274. Go to original source... Go to PubMed...




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