Urol. praxi. 2021;22(4):203-206 | DOI: 10.36290/uro.2021.026

Antihypertensive drugs and their impact on erectile function

MUDr. Jan Novák, FEBU, FECSM1, 2, prof. MUDr. Michal Vrablík, Ph.D.3
1 Urologická klinika VFN a 1. LF UK, Praha
2 Urologie a andrologie Gennet, s. r. o., Praha
3 III. interní klinika VFN a 1. LF UK, Praha

Erectile dysfunction is the most common male sexual dysfunction. Beside recognized risk factors, it may be caused also by the drugs used for the treatment of these conditions. Erection and its dysfunction are complex issues precluding isolated assessment of either factors. Although being aware of this complexity, authors are presenting an overview of impact of particular antihypertensive drugs on erectile function.

Keywords: erection, erectile dysfunction, antihypertensive drugs.

Accepted: June 9, 2021; Prepublished online: June 9, 2021; Published: November 24, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Novák J, Vrablík M. Antihypertensive drugs and their impact on erectile function. Urol. praxi. 2021;22(4):203-206. doi: 10.36290/uro.2021.026.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Salonia A, Bettocchi C, Carvalho J, et al. EAU Guidelines on Sexual and Reproductive Health. Edn. presented at the EAU Annual Congress Amsterdam 2020. Arnhem: EAU Guidelines Office; 2020.
    2. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993; 270(1): 83-90.
    3. Viigimaa M, Vlachopoulos C, Lazaridis A, Doumas M. Management of erectile dysfunction in hypertension: Tips and tricks. World J Cardiol. 2014; 6(9): 908-915. Go to original source... Go to PubMed...
    4. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994; 151(1): 54-61. Go to original source... Go to PubMed...
    5. Vaclová M, Vrablík M. Ateroskleróza v urologii. Urol. praxi 2015; 16(2): 66-9.
    6. Vrablík M, Janotová M, Motyková E, Prusíková M, Others. Endoteliální dysfunkce - první stadium aterosklerózy. Med. praxi 2011; 8(3): 119-22.
    7. Češka R. Interna. Triton; 2020.
    8. Kirby M, Jackson G, Simonsen U. Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract. únor 2005; 59(2): 225-9. Go to original source... Go to PubMed...
    9. Doumas M, Douma S. The effect of antihypertensive drugs on erectile function: a proposed management algorithm. J Clin Hypertens 2006; 8(5): 359-64. Go to original source... Go to PubMed...
    10. Manolis A, Doumas M. Antihypertensive treatment and sexual dysfunction. Curr Hypertens Rep. 2012; 14(4): 285-92. Go to original source... Go to PubMed...
    11. Pickering T, Shepherd A, Puddey I, et al. Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: A randomized controlled trial. American Journal of Hypertension. 2004; 17(12): 1135-42. Go to original source... Go to PubMed...
    12. Chrysant SG. Antihypertensive therapy causes erectile dysfunction. Curr Opin Cardiol. 2015; 30(4): 383-90. Go to original source... Go to PubMed...
    13. Turčan P, Pokorný P, Fait T. Sexuologie pro urology a gynekology. Maxdorf; 2012.
    14. Kittnar O. Lékařská fyziologie. Grada Publishing; 2020.
    15. Lincová D, Farghali H, Others. Základní a aplikovaná farmakologie. Druhé, doplněné a přepracované vydání. Galén; 2007.
    16. Düsing R. Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs. Drugs. 2005; 65(6): 773-86. Go to original source... Go to PubMed...
    17. Fogari R, Zoppi A. Effects of antihypertensive therapy on sexual activity in hypertensive men. Curr Hypertens Rep. 2002; 4(3): 202-10. Go to original source... Go to PubMed...
    18. Kobayashi K, Masumori N, Hisasue S-I, et al. Inhibition of Seminal Emission Is the Main Cause of Anejaculation Induced by a New Highly Selective α1A-Blocker in Normal Volunteers. J Sex Med. 2008; 5(9): 2185-90. Go to original source... Go to PubMed...
    19. Hisasue S-I, Furuya R, Itoh N, et al. Ejaculatory Disorder Induced by Alpha-Adrenergic Receptor Blockade is not Retrograde Ejaculation. J Urol. 2005; 173(4S): 290-290. Go to original source...
    20. Porst H, Oelke M, Goldfischer ER, et al. Efficacy and safety of tadalafil 5 mg once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: subgroup analyses of pooled data from 4 multinational, randomized, placebo-controlled clinical studies. Urology 2013; 82(3): 667-73. Go to original source... Go to PubMed...
    21. Hawthornský efekt [Internet]. [citován 19. květen 2021]. Dostupné z: https://cs.wikipedia.org/wiki/Hawthornsk%C3%BD_efekt.

    Return to the content


    Urology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.