O krůček blíže

doc. MUDr. Miroslav Hanuš, CSc.

Urol. praxi, 2011; 12(6): 331  

Metastatic renal cell carcinoma (mRCC), ten years of biological therapy: a help to patients or a waste of public health

MUDr.Michaela Matoušková, doc.MUDr.Miroslav Hanuš, CSc.

Urol. praxi, 2011; 12(6): 336-339  

insurance resources? Metastatic renal cell carcinoma is associated with a poor prognosis. The introduction of biological therapy only slowly changes the survival and quality of life of patients. Tyrosine kinase inhibitors, mTOR inhibitors and anti-VEGF monoclonal antibodies are approved by the regulatory bodies for the treatment of mRCC based on clinical trials. The therapeutic strategy is selected individually according to the staging of the disease, the performance status and comorbidities of the patient, and the expected treatment toxicity. The identification of prognostic factors for predicting survival allows to individualize therapeutic...

Bone metastasis in prostate cancer, recent recommendations for the administration of bisphosphonates

MUDr.Vít Vachalovský

Urol. praxi, 2011; 12(6): 340-344  

Prostate cancer occupies one of the leading positions in the incidence of cancer among men. A typical feature of this disease is its ability to metastasize to bones which predisposes the patients to skeletal related events (SRE). New konowledge of the pathophysiology field about the origin and development of metastases reveal new opportunity in the care for metastatic prostate cancer patients. Bisphosphonates significantly delay time to first SRE, reduce the risk of multiple events and improve quality of life of the patients. It is possible to use bisphosponates in prevention and treatment of cancer treatment-induced bone loss in men with androgen...

Nocturia - rational diagnosis and treatment

doc.MUDr.Jan Krhut, Ph.D., doc.MUDr.Roman Zachoval, Ph.D., MUDr.Ondřej Havránek, MUDr.David Němec, MUDr.Petr Holý

Urol. praxi, 2011; 12(6): 345-348  

Nocturia is one of the most bothersome symptoms of lower urinary tract and may be the leading symptom in medical examination. Nocturia has a special aspect of being of multifactorial ethiology so interdisciplinary approach for the diagnosis and treatment is obligatory. Nocturia is at present considered to be a new entity excluded from other symptoms of lower urinary tract and may be a consequence of serious disease. Diagnosis is based on non-invasive methods and the mainstay is the voiding diary. Treatment is based on desmopresin therapy and drugs influencing lower urinary tract in some cases.

Acute pain management in urology

MUDr.Marek Svítek

Urol. praxi, 2011; 12(6): 349-355  

Acute pain is an extremely unpleasant sensation. Although having a protective function, acute pain is also accompanied by a number of adverse effects, particularly when it is not treated appropriately. The basic procedures are based on the WHO three-step analgesic ladder and the Czech Society of Anaesthesiology and Intensive Care Medicine (ČSARIM) guidelines for management of acute postoperative pain. Radical treatment of acute pain, the use of multimodal approach including combinations of analgesics, techniques of regional anaesthesia and appropriate adjuvant agents are all essential. Continuous education of the attending staff is an integral...

Urinary tract infections in pregnancy: when to treat, how to treat, and what to treat with

MUDr.Jiří Kladenský

Urol. praxi, 2011; 12(6): 357-360  

Urinary tract infections (UTI) in pregnant women are a relatively frequent occurrence and the spectrum of these infections ranges from lower urinary tract disease (asymptomatic bacteriuria, acute cystitis) to upper urinary tract disease (acute pyelonephritis). Anatomical and functional changes in the urinary tract in pregnancy result in significantly higher susceptibility to progression of the infection from asymptomatic bacteriuria to the stage of acute pyelonephritis. Untreated asymptomatic bacteriuria in pregnancy leads, in as much as 40%, to the development of acute pyelonephritis with all the subsequent negative effects not only for the...

Erectile dysfunction - indicator of coronary artery disease and myocardial infarct

MUDr.Taťána Šrámková, CSc.

Urol. praxi, 2011; 12(6): 361-364  

Erectile dysfunction (ED) and coronary artery disease (CAD) have the same morphological base – endothelial dysfunction as a first stage of atherosclerosis. ED and CAD have the same risk factors, as a hypertension, dyslipidemia, diabetes mellitus, obesity, age, smoking and sedentary lifestyle. The time interval among the onset ED symptoms and the occurence of CAD symptoms and cardiovascular events is estimated at 2 – 3 years and 3 – 5 years respectively. ED is associated with increased all-cause mortality primarily due to increased cariovascular mortality. We should also actively screen these patients and treat them effectively.

Komentář urologa k článku dr. Čoupkové „Komplikace spojené s radioterapií karcinomu prostaty, jejich prevence a léčba“ (Urol. praxi, 2011; 12(5): 292-294) a článku dr. Macíka „Léčba urologických komplikací spojených s ozářením karcinomu prostaty“ (Urol. praxi 2011; 12(5): 295-297)

MUDr. Milan Král, Ph.D.

Urol. praxi, 2011; 12(6): 379  

Comparation of the surgical and pharmacological treatment of the urinary incontinence

MUDr.Vladimír Giblo, MUDr.Miroslav Louda, Ph.D., MUDr.Jaroslav Pacovský, Ph.D.

Urol. praxi, 2011; 12(6): 366-372  

Urinary incontinence is common and rather problematic disease occurring in the all spectrum of the population. Any kind of urinary incontinence is considered pathologic. Following paper is focused on feasibility of the medicament and surgical treatment in accordance with the incontinence type.

Iatrogenic ureteral trauma, abdominal catastrophe in terms of urologist

MUDr.Zdeněk Peremský, MUDr.Jiří Král, MUDr.Miloš Bočan, MUDr.Pavel Navrátil CSc., MUDr.Miloš Broďák Ph.D.

Urol. praxi, 2011; 12(6): 373-375  

The authors presents a case of iatrogenic complete and destructive ureteral injury during the complicated gynecological-general surgery operation, which was not during the operation recognized. They focus their attention on the causes, diagnosis and following solution of postoperative complication through the aid of ileal interposition.

Radiofrequency thermolesion of the ganglion impar in management of painful bladder syndrome - a case series

MUDr.Tomáš Gabrhelík, Ph.D., MUDr.Josef Košina, doc.MUDr.Milan Adamus, Ph.D., MUDr.Jan Neiser, doc.MUDr.Pavel Michálek, Ph.D.

Urol. praxi, 2011; 12(6): 376-379  

Painful bladder syndrome is characterized by symptoms of voiding dysfunction and chronic pelvic pain. There are indicated surgical therapy, neuromodulatory or neurodestructive techniques if conservative treatment failed. In three casuistic reports effect of radiofrequency thermolesion of a ganglion impar in the management of painful bladder syndrome is presented.

Vzpomínka na MUDr. Víta Vachalovského, odborného asistenta Urologické kliniky VFN a 1. LF UK Praha

prof. MUDr. Tomáš Hanuš, DrSc.

Urol. praxi, 2011; 12(6): 380  

Autodidaktický test 6/2011

Urol. praxi, 2011; 12(6): 381-382