Urol. praxi. 2024;25(4):218-221 | DOI: 10.36290/uro.2024.075

Male infertility and posibilities of pharmacological therapy

MUDr. Dalibor Jozef Fedák
Urologická klinika 2. LF UK a FN Motol, Praha

Historically rather ignored male infertility is alone or in combination the cause of approximately 60% infertile couples. Inability of couple to conceive leads to psychosocial stress. Role of systematic diagnostics and treatment of male infertility is to understand the cause, improve spermatogenesis and increase chances of successful fertilization.

Keywords: male infertility, semen analysis, pharmacotherapy.

Accepted: November 11, 2024; Published: November 25, 2024  Show citation

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Fedák DJ. Male infertility and posibilities of pharmacological therapy. Urol. praxi. 2024;25(4):218-221. doi: 10.36290/uro.2024.075.
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References

  1. Eisenberg ML, Esteves SC, Lamb DJ, et al. Male infertility. Nat Rev Dis Primers. 2023;9(1):1-22. Go to original source... Go to PubMed...
  2. Minhas S, Bettocchi C, Boeri L, et al. European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility. European Urology. 2021;80(5):603-620. Go to original source... Go to PubMed...
  3. Sharma A, Minhas S, Dhillo WS, et al. Male infertility due to testicular disorders. The Journal of Clinical Endocrinology & Metabolism. 2021;106(2):e442-459. Go to original source... Go to PubMed...
  4. Leisegang K, Sengupta P, Agarwal A, et al. Obesity and male infertility: Mechanisms and management. Andrologia. 2021;53(1):e13617. Go to original source... Go to PubMed...
  5. Uroweb - European Association of Urology [Internet]. [cited 2024 May 4]. MALE INFERTILITY - Uroweb. Available from: https://uroweb.org/guidelines/sexual-and-reproductive-health/chapter/male-infertility.
  6. Zveřina J. Poruchy mužské plodnosti. Urol. pro praxi. 2010;11(4):196-199.
  7. Kubíček V. Léčba neplodného muže. Urol. pro praxi. 2017;18(4):170-177. Go to original source...
  8. Kubíček V. Léčba neplodného muže: při správné indikaci má lepší výsledky než asistovaná reprodukce | Aktuality z medicíny | Terapie [Internet]. [cited 2024 May 4]. Available from: https://www.terapie.digital/terapie/medicina/lecba-neplodneho-muze-pri-spravne-indikaci-ma-lepsi-vysledky-nez-asistovana-reprodukce.html?authToken=null#.
  9. Boitrelle F, Shah R, Saleh R, et al. The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis. Life (Basel). 2021;11(12):1368. Go to original source... Go to PubMed...
  10. Alahmar AT, Singh R, Palani A. Sperm DNA Fragmentation in Reproductive Medicine: A Review. J Hum Reprod Sci. 2022;15(3):206-218. Go to original source... Go to PubMed...
  11. Zambrano Serrano CA, Carvajal Obando A. Diagnosis and hormonal treatment of male infertility. Actas Urol Esp (Engl Ed). 2020;44(5):321-327. Go to original source... Go to PubMed...
  12. Kazmi SRH, Can AS. Luteinizing Hormone Deficiency. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 May 20]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK562219/.
  13. Gunes S, Esteves SC. Role of genetics and epigenetics in male infertility. Andrologia [Internet]. 2021 Feb [cited 2024 May 20];53(1). Available from: https://onlinelibrary.wiley.com/doi/10.1111/and.13586. Go to original source... Go to PubMed...
  14. Bieniek JM, Lapin CD, Jarvi KA. Genetics of CFTR and male infertility. Transl Androl Urol. 2021;10(3):1391-1400. Go to original source... Go to PubMed...
  15. Mann U, Shiff B, Patel P. Reasons for worldwide decline in male fertility. Curr Opin Urol. 2020;30(3):296-301. Go to original source... Go to PubMed...
  16. Novák J. Reprodukční medicína nejen pro urology. Maxdorf Jessenius; 2023: 162 p.
  17. Kaltsas A. Oxidative Stress and Male Infertility: The Protective Role of Antioxidants. Medicina (Kaunas). 2023;59(10):1769. Go to original source... Go to PubMed...
  18. Steiner AZ, Hansen KR, Barnhart KT, et al. The effect of anti­oxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility and Sterility. 2020;113(3):552-560.e3. Go to original source... Go to PubMed...
  19. Del Giudice F, Busetto GM, De Berardinis E, et al. A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility. Asian J Androl. 2020;22(4):360-367. Go to original source... Go to PubMed...
  20. Turjap M, Král R, Juřica J. Anastrozole - off­‑label use in men. Prakt Lékáren. 2023;19(1):11-14. Go to original source...
  21. SPC ANASTROZOL VIATRIS 1MG Potahovaná tableta. (2024). Státní ústav pro kontrolu léčiv [Internet], SÚKL: ©2010 [cit. 15.05.2024]. Available from: https://prehledy.sukl.cz/prehled_leciv.html#/leciva/0279200.
  22. Cannarella R, Condorelli RA, Mongioì LM, et al. Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis. Expert Opin Pharmacother. 2019;20(12):1517-1525. Go to original source... Go to PubMed...
  23. Sadeghi S, Reza Talebi A, Shahedi A, et al. Effects of different doses of tamoxifen on the sperm parameters and chromatin quality in mice: An experimental model. Int J Reprod Biomed. 2019;17(4):279-286. Go to original source... Go to PubMed...
  24. Methorst C, Faix A, Huyghe E. [Medical treatments for male infertility]. Prog Urol. 2023;33(13):653-680. Go to original source... Go to PubMed...
  25. SPC TAMOXIFEN EBEWE 20MG Tableta. (2024). Státní ústav pro kontrolu léčiv [Internet], SÚKL: ©2010 [cit. 15.05.2024]. Available from: https://prehledy.sukl.cz/prehled_leciv.html#/leciva/0032001.
  26. SPC BREVACTID 1500IU Prášek a rozpouštědlo pro injekční roztok.(2024). Státní ústav pro kontrolu léčiv [Internet], SÚKL: ©2010 [cit. 15.05.2024]. Available from: https://mediately.co/cz/drugs/Ah1GxW1ZTCgzVZLocrWT0UU2TQX/brevactid-1500iu-prasek-a-rozpoustedlo-pro-injekcni-roztok.
  27. Esposito M, Salerno M, Calvano G, et al. Impact of anabolic androgenic steroids on male sexual and reproductive function: a systematic review. Panminerva Med. 2023;65(1):43-50. Go to original source... Go to PubMed...




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