Urol. praxi. 2024;25(4):180-184 | DOI: 10.36290/uro.2024.068

New approaches in the treatment of testicular cancer

MUDr. Pavel Navrátil, FEBU^{1, 2}, MUDr. Minh Nguyet Tranová¹, MUDr. Jiří Špaček, FEBU^{1, 2}, MUDr. Michal Balík, Ph.D.^{1, 2}, doc. MUDr. Jaroslav Pacovský, Ph.D.^{1, 2}

¹ Urologická klinika, Fakultní nemocnice Hradec Králové

² Lékařská fakulta v Hradci Králové, Univerzita Karlova

Testicular germ cell tumors represent a significant challenge in the field of oncology, despite their relatively low incidence. This article focuses on current approaches in their treatment, emphasizing the optimization of care and minimizing the risk of relapse and treatment toxicity. Standard procedures such as orchiectomy, chemotherapy, radiotherapy, and lymphadenectomy are discussed. Special attention is given to the role of new biomarkers, such as miR-371a-3p, which improve the accuracy of diagnosis and treatment monitoring. The article also reflects current trends in therapy de-escalation and research of new targeted therapeutic approaches, including currently studied substances and drug combinations. There is a need for a personalized approach in the treatment of these tumors allowing better outcomes while reducing side effects of the therapy.

Keywords: testicular cancer, orchiectomy, chemotherapy, radiotherapy.

Accepted: November 11, 2024; Published: November 25, 2024  Show citation