Urol. praxi. 2017;18(5):223-226 | DOI: 10.36290/uro.2017.052

Fixed combination of hyaluronate and chondroitin sulfate recurrent cystitis

MUDr. Jiří Slíva, Ph.D.
Ústav farmakologie 3. LF UK, Praha

Hyaluronic acid and chondroitin sulfate are widely distributed glycosaminoglycans throughout the human body. Among others,they also cover the bladder surface and the disruption of their layer may result in a higher incidence of urinary tract infections(IMC). This text discusses the possibilities of their intravesical application in order to reduce the recurrence of IMC, however, theyalso play a role in the treatment of bladder painful syndrome or in men with prostate cancer after radiotherapy.

Keywords: IMC, prostatic cancer, GAG, recurrence, BPS/IC, chondroitin sulfate, hyaluronic acid, cystitis

Published: December 1, 2017  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Slíva J. Fixed combination of hyaluronate and chondroitin sulfate recurrent cystitis. Urol. praxi. 2017;18(5):223-226. doi: 10.36290/uro.2017.052.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Collins AJ, Foley RN, Herzog C, et al. US Renal Data System 2012 Annual Data Report. Am J Kidney Dis. 2013; 61: A7, e1-A7, 476. Go to original source... Go to PubMed...
    2. De Vita D, Antell H, Giordano S. Effectiveness of intravesical hyaluronic acid with or without chondroitin sulfate for recurrent bacterial cystitis in adult women: a meta-analysis. Int Urogynecol.J 2013; 24: 545-552. Go to original source... Go to PubMed...
    3. Tasdemir S, Tasdemir C, Vardi N, et al. Intravesical hyaluronic acid and chondroitin sulfate alone and in combination for urinary tract infection: assessment of protective effects in a rat model. Int. J Urol. 2012; 19: 1108-1112. Go to original source...
    4. Salonia A. New preclinical data - the case for Ialuril(R). Urologia. 2016; 83(Suppl 1): 15-19. Go to original source... Go to PubMed...
    5. Costantini E, Lazzeri M, Pistolesi D, et al. Morphological changes of bladder mucosa in patients who underwent instillation with combined sodium hyaluronic acid-chondroitin sulphate (Ialuril(R)). Urol.Int. 2013; 91: 81-88. Go to original source... Go to PubMed...
    6. Cvach K, Rosamilia A. Review of intravesical therapies for bladder pain syndrome/interstitial cystitis. Transl.Androl Urol 2015; 4: 629-637. Go to PubMed...
    7. Cervigni M, Natale F, Nasta L, Padoa A, Voi RL, Porru D. A combined intravesical therapy with hyaluronic acid and chondroitin for refractory painful bladder syndrome/interstitial cystitis. Int Urogynecol.J Pelvic.Floor.Dysfunct. 2008; 19: 943-947. Go to original source...
    8. Porru D, Leva F, Parmigiani A, et al. Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. Int Urogynecol. J 2012; 23: 1193-1199. Go to original source... Go to PubMed...
    9. Giberti C, Gallo F, Cortese P, Schenone M. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv. Urol 2013; 5: 175-179. Go to original source... Go to PubMed...
    10. Morelli M, Mocciaro R, Venturella R, Albano A, Sacchinelli A, Zullo F. Hyaluronic acid-chondroitin sulfate: a potential factor to select pure stress urinary incontinence in patients with interstitial cystitispainful bladder syndrome and mixed incontinence symptoms. Minerva Ginecol. 2015; 67: 121-125. Go to PubMed...
    11. Cervigni M, Sommariva M, Tenaglia R, et al. A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol. Urodyn. 2017; 36: 1178-1186. Go to original source...
    12. Damiano R, Quarto G, Bava I, et al. Prevention of recurrent urinary tract infections by intravesical administration of hyaluronic acid and chondroitin sulphate: a placebo-controlled randomised trial. Eur Urol. 2011; 59: 645-651. Go to original source... Go to PubMed...
    13. De Vita D, Giordano S. Effectiveness of intravesical hyaluronic acid/chondroitin sulfate in recurrent bacterial cystitis: a randomized study. Int Urogynecol. J 2012; 23: 1707-1713. Go to original source... Go to PubMed...
    14. Torella M, Schettino MT, Salvatore S, Serati M, De FP, Colacurci N. Intravesical therapy in recurrent cystitis: a multi-center experience. J Infect. Chemother. 2013; 19: 920-925. Go to original source... Go to PubMed...
    15. Cicione A, Cantiello F, Ucciero G, et al. Restoring the glycosaminoglycans layer in recurrent cystitis: experimental and clinical foundations. Int J Urol 2014; 21: 763-768. Go to original source...
    16. Gugliotta G, Calagna G, Adile G, et al. Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. Taiwan. J Obstet. Gynecol. 2015; 54: 537-540. Go to original source... Go to PubMed...
    17. Ciani O, Arendsen E, Romancik M, et al. Intravesical administration of combined hyaluronic acid (HA) and chondroitin sulfate (CS) for the treatment of female recurrent urinary tract infections: a European multicentre nested case-control study. BMJ Open. 2016; 6: e009669. Go to original source... Go to PubMed...
    18. Fersino S, Fiorentino A, Giaj LN, et al. Impact of Ialuril Soft Gels in reducing urinary toxicity during radical hypofractionated radiotherapy in prostate cancer: a preliminary experience. Minerva Urol Nefrol. 2016; 68: 9-13. Go to PubMed...
    19. Gacci M, Saleh O, Giannessi C, et al. Sodium hyaluronate and chondroitin sulfate replenishment therapy can improve nocturia in men with post-radiation cystitis: results of a prospective pilot study. BMC Urol 2015; 15: 65. Go to original source... Go to PubMed...
    20. Gacci M, Saleh O, Giannessi C, et al. Bladder Instillation Therapy With Hyaluronic Acid and Chondroitin Sulfate Improves Symptoms of Postradiation Cystitis: Prospective Pilot Study. Clin Genitourin. Cancer 2016; 14: 444-449. Go to original source... Go to PubMed...
    21. Lazzeri M, Hurle R, Casale P, et al. Managing chronic bladder diseases with the administration of exogenous glycosaminoglycans: an update on the evidence. Ther Adv. Urol 2016; 8: 91-99. Go to original source... Go to PubMed...

    Return to the content


    Urology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.