Urol. praxi. 2017;18(2):64-68 | DOI: 10.36290/uro.2018.041

New diagnostic options and prognosis prediction of urinary bladder cancer

MUDr. Milan Král, Ph.D., MUDr. David Hradil, MUDr. Šárka Kudláčková, MUDr. Aleš Vidlář, Ph.D., FEBU, doc. MUDr. Vladimír Študent, Ph.D.

Urologická klinika LF UP a FN Olomouc

High cancer recurrence is typical for urinary bladder tumors regardless of radically performed transurethral surgery. The explanation lies in genetic information of urothelial cells but also in unrevealing all malignant areas in the bladder during cystoscopy or transurethral resection. Diagnostic improvement can be reached by using new endoscopic techniques which precise resolution between normal and pathological bladder mucosa. Further improvement and individualisation of the therapy can be reached by prognostic markers analysis which can identify metastatic status of the disease e.g. by using circulating tumor cells dispite invisible metastasis on imaging methods. In the future, we should be able to define patients who would profit from early start of multimodal therapy and, concurently, we could increase the chance of local cancer control and curability of combined surgical and oncological therapy.

Keywords: bladder cancer, diagnostic, narrow band imaging, photodynamic diagnostic, markers

Received: August 7, 2018; Accepted: November 7, 2018; Prepublished online: November 7, 2018; Published: May 1, 2017  Show citation