Urolog. pro Praxi, 2010; 11(4): 200-203
Cushingův syndrom, karcinom nadledviny, hyperkortikalizmus, mineralokortikoidy, aldosteron, glukokortikoidy, kortizol, adrenální
- 1 Urologické oddělení Masarykovy nemocnice v Ústí nad Labem a Centrum robotické chirurgie KZ, a. s., Ústí nad Labem
- 2 Oddělení patologické anatomie MNUL, KZ a. s., Ústí nad Labem
- 3 Radiodiagnostické oddělení MNUL, KZ a. s., Ústí nad Labem
androgeny, estrogeny, MEN I.
Adrenocortical carcinoma
Adrenocortical carcinomas are malignant tumours arising from the cells of the adrenal cortex. It is common for them to be hormonally
active. They are a frequent cause of clinically evident ACTH-independent Cushing‘s syndrome. Their growth is typically very rapid. The
cells of these adrenal carcinomas are usually poorly differentiated. If the tumour is hormonally active, it is manifested by overproduction
of some of the hormones. Thus, hyperaldosteronism, hypercorticalism without virilization or hyperandrogenism can be encountered.
Adrenocortical carcinomas are highly malignant. Both imaging methods and specific tests are required to diagnose them. The treatment
is surgical and adjuvant therapy usually fails to have the desired effect.
androgens, oestrogens, MEN I.
Keywords: adrenocortical carcinoma, malignant tumour of the adrenal cortex, adrenal adenoma, Cushing‘s syndrome, ACTH-independent Cushing‘s syndrome, adrenal carcinoma, hypercorticalism, mineralocorticoids, aldosterone, glucocorticoids, cortisol, adrenal
Published: September 1, 2010 Show citation
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