Urolog. pro Praxi, 2010; 11(1): 32-35

Histologic finding of the tumor necrosis in the clear cell renal cancer specimen - the negative prognostic factor

MUDr.Jaroslav Pacovský, Ph.D.1, MUDr.Miloš Broďák, Ph.D.1, MUDr.Petr Hušek1, MUDr.Lukáš Holub1, MUDr.Josef Košina1, MUDr.Pavel Navrátil, CSc.1, MUDr.Miroslav Louda, Ph.D.1, MUDr.Miroslav Podhola, Ph.D.2
1 Urologická klinika FN a LF UK v Hradci Králové
2 Fingerlandův ústav patologie FN a LF UK v Hradci Králové

Objective and methods: The retrospective analysis of the 228 removed renal cancers. The renal clear cell cancer necrosis incidence, the tumor

specific mortality and time from the surgery was evaluated.

Results: Overall 190 renal clear cell cancers were confirmed in the group of the 228 tumors. The tumor necrosis (necro+) was found in 53

patients (27.8 %), in this cohort N+ was found in 15 patients (28.3 %) and M+ was found in 15 patients (28.3 %). Tumor specific mortality

was confirmed in 67.9 % in median 8 months in necro+ group and, in 100 % in median 5 months in N+ group and in 100 % in median 5

months in M+ group.

Conclusion: The necrosis of the renal clear cell cancer is a serious prognostic factor associates with the 67.9 % mortality rate. This factor

is dependent on tumor size, is in dependent on nuclear grade and is associated with clinical stage of the disease.

Keywords: renal clear cell cancer, necrosis, prognosis

Published: March 1, 2010  Show citation

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Pacovský J, Broďák M, Hušek P, Holub L, Košina J, Navrátil P, et al.. Histologic finding of the tumor necrosis in the clear cell renal cancer specimen - the negative prognostic factor. Urol. praxi. 2010;11(1):32-35.
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