Urol. praxi. 2025;26(4):220-225 | DOI: 10.36290/uro.2025.091

Antibiotics and drug interactions in urology

PharmDr. Aleš Šorf, Ph.D.¹, PharmDr. Petr Domecký, Ph.D.^{1, 2}

¹ Katedra sociální a klinické farmacie, Farmaceutická fakulta Univerzity Karlovy v Hradci Králové, Hradec Králové

² OAKS Consulting s. r. o., Praha

Urinary tract infections represent the second most common group of bacterial infections in the general population, and their diagnostic and therapeutic management requires careful consideration of multiple factors. Key determinants include the location and severity of the infection, the risk of recurrence, and local epidemiological data on anti­biotic resistance. Antibiotics from different classes vary in their pharmacokinetic and pharmacodynamic profiles, which influence their potential to cause clinically significant drug interactions. These interactions can substantially impact treatment outcomes, either by leading to therapeutic failure or by increasing the risk of drug toxicity. To minimize the impact of drug interactions, it is essential to conduct a thorough medical history assessment, promptly identify at-risk patients - particularly those with multimorbidity or polypharmacy - and ensure continuous monitoring throughout treatment. The aim of this article is to provide an overview of key drug interactions associated with antibio­tics most commonly used in the treatment of urinary tract infections and to outline approaches for their monitoring and management in clinical practice.

Keywords: drug interactions, antibiotics, urinary tract infections.

Accepted: November 24, 2025; Published: December 16, 2025  Show citation