369 www.urologiepropraxi.cz3408040010765133201214261288335354403453471515565592639689716757797816832872911 /35688040010732 Urol.3645804001075682129149164 praxi.3829804001075077118158177193 2025;26(2):102-1074042804001074487128172185229272295338360375412452493518557596638 /47258040010731 UROLOGIE48028040010756103166209268327348392 PRO5215804001074592154 PRAXI5391804001074591147200220 10556558020012657111168 LÉKOVÉ4672200012653110178251318376 INTERAKCE5070200012630104163220285357424484542 Karcinom372736001063375111145163204245299 prostaty404136001063368109142174211239278 –4335360010645 interakční43963600106155688120156198233266307325 potenciál473736001063273104136177212230270300 používaných505336001063374115147165203239280318350391 léčiv54603600106296196114152 Tab.34062001124991145167 1.52362001125070 Rizikové6366200107446195113148192229265 a915620010745 nedoporučované97562001104993141190239288320368406455497544594637 lékové16266200107195692135172208 kombinace184862001073781151196213258303339375 Relugolix909760095408098140184227245262297 Bikalutamid1377760095405791129146189214251317334378 Enzalutamid19017600953780113151168211236273339356400 Apalutamid24687600954791129146188214251317334378 Darolutamid30217600955288112154172214240277343359403 Abirateron36307600954792109133170195233257299343 Olaparib41697600955472108152190214231275 Niraparib4665760095516892129173211234252296 Talazoparib5147760095376986122156198243280304321366 Omeprazol37189009554120160204229266299342359 ↓1901890011940 omeprazol195889009543109148193217255288330348 ↓2468890011940 omeprazol252588009845114156204233275312358379 Pantoprazol37110100954076119143185230254292325367385 ↑30211010011938 pantoprazol307610100954481125149191235260297331373391 Lansoprazol37111300953674117147190235259296330372390 ↓24681140011940 lansoprazol252511300982162108142188236266307344390411 Esomeprazol37112600953768112178218262286324357399417 ↓24681260011940 esomeprazol252112600984174118185226272300340375419439 Metoklopramid37113800915996119159191208248290313348409425466 ↑36301390011135 metoklopramid367313900886195116152182197234273293325384397435 Domperidon37115000955296162206246270288332375419 ↓19011500011940 domperidon195815000954487153197238262279323366410 ↓24681500011940 domperidon252515000954487153197238262279323366410 Ondansetron37116300955498142178221251291316340382426 ↓19011630011940 ondansetron195816300954386130167210240279304329371414 ↓24681630011940 ondansetron252516300954386130167210240279304329371414 Aprepitant37117500954791116154199216241279322346 ↓19011750011940 aprepitant195817500984188118160207229258300346374 ↓24681750011940 aprepitant252517500984188118160207229258300346374 ↑41691750011938 olaparib42241750095436097141178202220264 Naloxegol37118700955188105148182221266309327 ↓19011880011940 naloxegol195818700984687108154194235282328350 ↓24681880011940 naloxegol252518700984687108154194235282328350 Metformin371200009562102127151194218284301344 ↑46652000011938 metformin4720200009566105130154197221287304347 Gliklazid3712120095506885118137173207224268 ↓19012120011940 gliklazid19582120095446177111130166200217261 Pioglitazon3712250095405699144161178203240274316360 ↑36302250011938 pioglitazon368522500954462105149167183209246279321365 Saxagliptin37123700953774110147191208225269294311354 ↓19012370011940 saxagliptin195823700953067103140184201218262287304347 ↓24682370011940 saxagliptin252523700953067103140184201218262287304347 Linagliptin3712490095365396133177194211255280297340 ↓19012500011940 linagliptin19582500095173477113157174191236260277320 ↓24682500011940 linagliptin25252500095173477113157174191236260277320 Repaglinid37126200954080124162206223240283300344 ↓19012620011940 repaglinid195826200952462107144188205222265282326 ↓24682620011940 repaglinid252526200952462107144188205222265282326 ↑36302620011938 repaglinid368526200952462107144188205222265282326 Warfarin371274009566101125149187211228271 ↑13762740011938 warfarin143227400955895119143181204222265 ↓19012740011940 warfarin195827400955895119143181204222265 ↓24682740011940 warfarin252527400955895119143181204222265 ↑36302740011938 warfarin368527400955895119143181204222265 Klopidogrel37128700954059102147164208251296320359376 ↑19012870011938 enzalutamid195628600984188125167189235264305374395442 ↓24682870011940 klopidogrel25252870095345296141158202245290314352370 ↓36302870011940 klopidogrel36882870095345296141158202245290314352370 Tikagrelol3712990095375690128172196235252295313 ↓19012990011940 tikagrelol19582990098284990132179208250272318340 ↓24682990011940 tikagrelol25252990098284990132179208250272318340 Dabigatran37131100955288133150194231255279316360 ↑19013120011938 dabigatran195631200954480124142186222247271308351 ↓24683120011940 dabigatran252531100984688135157203245273302344390 ↑36303120011938 dabigatran368531200954480124142186222247271308351 ↑41693120011938 olaparib42243120095436097141178202220264 Rivaroxaban3713240095405895132156198232269314351394 ↓19013240011940 rivaroxaban19583240098285091133162208247288336378424 ↓24683240011940 rivaroxaban25253240098285091133162208247288336378424 ↑30213240011938 rivaroxaban30763240098285091133162208247288336378424 ↑36303240011938 rivaroxaban36853240098285091133162208247288336378424 Apixaban37133600954791109144181225263306 ↓19013360011940 apixaban195833600984188110150191239281327 ↓24683360011940 apixaban252533600984188110150191239281327 ↑30213360011938 apixaban307633600984188110150191239281327 ↑36303360011938 apixaban368533600984188110150191239281327 Edoxaban37134900953781124158195240277320 ↑19013490011938 edoxaban195634900953984127161198243280323 ↓24683490011940 edoxaban252534800984189135174216263305351 ↑36303490011938 edoxaban368534900953984127161198243280323 Digoxin37136100955269113156191208251 ↑19013610011938 digoxin195636100954460104148182199242 ↓24683610011940 digoxin252536100954460104148182199242 ↑41693610011938 digoxin422436100954460104148182199242 Propafenon37137300954063106150188209248291335378 ↑9093740011938 relugolix9643730098287192138185231253274315 ↓19013740011940 propafenon196137400954468111156193214253296340383 ↓24683740011940 propafenon252537400954468111156193214253296340383 ↑36303740011938 propafenon368537400954468111156193214253296340383 ↑51473740011938 talazoparib52003730098286990130167212259299328348395 Amiodaron371386009547113130173218254278320364 ↑9093860011938 relugolix9643860098287192138185231253274315 ↓19013860011940 amiodaron1958386009536102119162207243267309353 ↓24683860011940 amiodaron2525386009536102119162207243267309353 ↑51473860011938 talazoparib52003860098286990130167212259299328348395 Ivrabradin3713980095175478116160184222266283326 ↑13763980011938 ivabradin14323980095175491135160197241258301 ↓19013980011940 ivabradin195839800982062103151180222269290337 ↓24683980011940 ivabradin252539800982062103151180222269290337 Diosmin37141100955269112142208225268 ↑9094110011938 relugolix9644110095246280122166210227244279 ↑51474110011938 talazoparib52024110095256279115149191236273297315359 Bosentan37142300954084114154197221258301 ↓41694230011940 olaparib422642300984567108156197227248295 Metoprolol371435009562102127169214238280298341359 ↑36304360011938 metoprolol3685436009566105130172217241283301345362 Bisoprolol3714480095405887130175200242260303321 ↓19014480011940 bisoprolol19584480095446291134179204246264307325 ↓24684480011940 bisoprolol25254480095446291134179204246264307325 Nebivolol37146000955191135153189232250293311 ↑36304600011938 nebivolol368546000954383127144181224242285303 Karvedilol37147300954078102141180225242259302320 ↑9094730011938 relugolix9644720098287192138185231253274315 ↑36304730011938 karvedilol36854730095347296135174219236253296314 ↑51474730011938 talazoparib52004720098286990130167212259299328348395 Amlodipin371485009547113130173218235279297340 ↓19014850011940 amlodipin1958485009536102119163207224269286329 ↓24684850011940 amlodipin2525485009536102119163207224269286329 Nifedipin3714970095516890129173190235252295 ↓19014980011940 nifedipin19584980095436081120165182226244287 ↓24684980011940 nifedipin25254980095436081120165182226244287 Felodipin3715100095377593136181198242260303 ↓19015100011940 felodipin19585100095216077121166182227244287 ↓24685100011940 felodipin25255100095216077121166182227244287 ↑51475100011938 talazoparib52025100095256279115149191236273297315359 Isradipin3715220095174670107152168213230273 ↓19015220011940 isradipin19585220095174670107151168213230273 ↓24685220011940 isradipin25255220095174670107151168213230273 Lerkanidipin3715350095367498133171214231275292336353396 ↓19015350011940 lerkanidipin19585350095175680115153196213257274318335378 ↓24685350011940 lerkanidipin25255350095175680115153196213257274318335378 Nimodipin37154700955168134177222239283301343 ↑13765470011938 nimodipin143254700954360125169214231275292335 ↓19015470011940 nimodipin195854700984667135181229251298319366 ↓24685470011940 nimodipin252554700984667135181229251298319366 ↓30215470011940 nimodipin307854700954360125169214231275292335 Lacidipin37155900953674110127171188232250293 ↓19015600011940 lacidipin19615600095175390107151168212229272 ↓24685600011940 lacidipin25255600095175390107151168212229272 Verapamil37157200954178102139183221286303320 ↑9095720011938 relugolix9645720098287192138185231253274315 ↑13765720011938 bikalutamid14325720095446296133151193219256321338382 ↓19015720011940 verapamil19585720095367599136181218284300318 ↓24685720011940 verapamil25255720095367599136181218284300318 ↑41695720011938 olaparib422457200984567108156197227248295 ↑51475720011938 talazoparib52005720098286990130167212259299328348395 Diltiazem3715840095526986111128165198237302 ↑9095840011938 relugolix9645840095246280122166210227244279 ↓19015840011940 diltiazem19585840095446077103120156189228294 ↓24685840011940 diltiazem25255840095446077103120156189228294 ↑41695840011938 olaparib422458400984567108156197227248295 ↑51475840011938 talazoparib52025840095256279115149191236273297315359 Losartan37159700953678108146170197235278 ↓19015970011940 losartan19585970095176090128152179217260 Valsartan3716090095417693123160184212249292 ↑30216090011938 valsartan30766090095367391120157181209246289 Simvastatin37162100953754119155192222248285310327370 ↑13766220011938 simvastatin143262200953046112148185215241278302320362 ↓19016220011940 simvastatin195862200953046112148185215241278302320362 ↓24686220011940 simvastatin252562200953046112148185215241278302320362 ↑30216220011938 simvastatin307662200953046112148185215241278302320362 ↑36306220011938 simvastatin368562200953046112148185215241278302320362 ↑41696220011938 simvastatin422462200953046112148185215241278302320362 ↑46656220011938 simvastatin472062200953046112148185215241278302320362 Lovastatin37163400953678114152182208245269286329 ↓19016340011940 lovastatin19586340095176096134164190227251268311 ↓24686340011940 lovastatin25256340095176096134164190227251268311 Atorvastatin37164600954771112137176213243269307331348391 ↓19016460011940 atorvastatin195864600953661103127166204234260297321338381 ↓24686460011940 atorvastatin252564600953661103127166204234260297321338381 ↑30216460011938 atorvastatin307664600953661103127166204234260297321338381 ↑36306460011938 atorvastatin368564600953661103127166204234260297321338381 ↑41696460011938 atorvastatin422364600953661103127166204234260297321338381 ↑46656460011938 atorvastatin47176460095365999122160196224248284307322364 ↑51476460011938 talazoparib52026460095256279115149191236273297315359 Rosuvastatin37165900954084114156193230260286323348365408 ↓24686590011940 rosuvastatin25256590095246696138175212242268306330347390 ↑30216590011938 rosuvastatin307665800982874108154196237271301343371392438 ↑36306590011938 rosuvastatin36856590095246696138175212242268306330347390 ↑41696590011938 rosuvastatin42226590095246594136172208237263299323339381 ↑46656590011938 rosuvastatin47146590095246493133169204233257293316331372 Ezetimib37167100953772110136153218235279 ↑30216710011938 ezetimib307667100953972111136153219235280 Mirabegron37168300956280103141185225270294336380 ↓19016840011940 mirabegron195868400956682106144188228273297339383 ↓24686840011940 mirabegron252568400956682106144188228273297339383 Solifenacin3716960095378198115137176219255292309352 ↓19016960011940 solifenacin19586960095307391108129168212248284301344 ↓24686960011940 solifenacin25256960095307391108129168212248284301344 Fesoteridin37170800953775106149174212236253297314357 ↓24687080011940 fesoteridin25257080095216090134158196220238282299342 Sildenafil3717210095375471115154197234255273290 ↓19017210011940 sildenafil19587210095304663108147190227248266283 ↓24687210011940 sildenafil25257210095304663108147190227248266283 Tadalafil37173300953769113150167203224242259 ↓19017330011940 tadalafil195873300952562106143160196218235253 ↓24687330011940 tadalafil252573300952562106143160196218235253 Tamsulosin37174500953769134164206224267297313356 ↑36307460011938 tamsulosin368574600952562128157199217260290307349 Silodosin3717580095375471114159202232249292 ↑19017580011938 silodosin19567580095304663107151195225241284 Dexametazon37177000955292128165230270295332366408451 ↓19017700011940 dexametazon195877000954483119156221261286323357399443 ↓24687700011940 dexametazon252477000954482117153218257281318350392435