www.urologiepropraxi.cz / Urol. praxi. 2025;26(2):102-107 / UROLOGIE PRO PRAXI 105 LÉKOVÉ INTERAKCE Karcinom prostaty – interakční potenciál používaných léčiv Tab. 1. Rizikové a nedoporučované lékové kombinace Relugolix Bikalutamid Enzalutamid Apalutamid Darolutamid Abirateron Olaparib Niraparib Talazoparib Omeprazol ↓ omeprazol ↓ omeprazol Pantoprazol ↑ pantoprazol Lansoprazol ↓ lansoprazol Esomeprazol ↓ esomeprazol Metoklopramid ↑ metoklopramid Domperidon ↓ domperidon ↓ domperidon Ondansetron ↓ ondansetron ↓ ondansetron Aprepitant ↓ aprepitant ↓ aprepitant ↑ olaparib Naloxegol ↓ naloxegol ↓ naloxegol Metformin ↑ metformin Gliklazid ↓ gliklazid Pioglitazon ↑ pioglitazon Saxagliptin ↓ saxagliptin ↓ saxagliptin Linagliptin ↓ linagliptin ↓ linagliptin Repaglinid ↓ repaglinid ↓ repaglinid ↑ repaglinid Warfarin ↑ warfarin ↓ warfarin ↓ warfarin ↑ warfarin Klopidogrel ↑ enzalutamid ↓ klopidogrel ↓ klopidogrel Tikagrelol ↓ tikagrelol ↓ tikagrelol Dabigatran ↑ dabigatran ↓ dabigatran ↑ dabigatran ↑ olaparib Rivaroxaban ↓ rivaroxaban ↓ rivaroxaban ↑ rivaroxaban ↑ rivaroxaban Apixaban ↓ apixaban ↓ apixaban ↑ apixaban ↑ apixaban Edoxaban ↑ edoxaban ↓ edoxaban ↑ edoxaban Digoxin ↑ digoxin ↓ digoxin ↑ digoxin Propafenon ↑ relugolix ↓ propafenon ↓ propafenon ↑ propafenon ↑ talazoparib Amiodaron ↑ relugolix ↓ amiodaron ↓ amiodaron ↑ talazoparib Ivrabradin ↑ ivabradin ↓ ivabradin ↓ ivabradin Diosmin ↑ relugolix ↑ talazoparib Bosentan ↓ olaparib Metoprolol ↑ metoprolol Bisoprolol ↓ bisoprolol ↓ bisoprolol Nebivolol ↑ nebivolol Karvedilol ↑ relugolix ↑ karvedilol ↑ talazoparib Amlodipin ↓ amlodipin ↓ amlodipin Nifedipin ↓ nifedipin ↓ nifedipin Felodipin ↓ felodipin ↓ felodipin ↑ talazoparib Isradipin ↓ isradipin ↓ isradipin Lerkanidipin ↓ lerkanidipin ↓ lerkanidipin Nimodipin ↑ nimodipin ↓ nimodipin ↓ nimodipin ↓ nimodipin Lacidipin ↓ lacidipin ↓ lacidipin Verapamil ↑ relugolix ↑ bikalutamid ↓ verapamil ↓ verapamil ↑ olaparib ↑ talazoparib Diltiazem ↑ relugolix ↓ diltiazem ↓ diltiazem ↑ olaparib ↑ talazoparib Losartan ↓ losartan Valsartan ↑ valsartan Simvastatin ↑ simvastatin ↓ simvastatin ↓ simvastatin ↑ simvastatin ↑ simvastatin ↑ simvastatin ↑ simvastatin Lovastatin ↓ lovastatin ↓ lovastatin Atorvastatin ↓ atorvastatin ↓ atorvastatin ↑ atorvastatin ↑ atorvastatin ↑ atorvastatin ↑ atorvastatin ↑ talazoparib Rosuvastatin ↓ rosuvastatin ↑ rosuvastatin ↑ rosuvastatin ↑ rosuvastatin ↑ rosuvastatin Ezetimib ↑ ezetimib Mirabegron ↓ mirabegron ↓ mirabegron Solifenacin ↓ solifenacin ↓ solifenacin Fesoteridin ↓ fesoteridin Sildenafil ↓ sildenafil ↓ sildenafil Tadalafil ↓ tadalafil ↓ tadalafil Tamsulosin ↑ tamsulosin Silodosin ↑ silodosin Dexametazon ↓ dexametazon ↓ dexametazon
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